Wissenschaftliche Beiträge/Kommentare

2006-2010 Autor in allen Ausgaben des „Der Diabetologe"
Springer Verlag Heidelberg

2007 Buchkapitel: Brehm A, Roden M 2007 Glucose clamp techniques
Chapter 4:43-77. In „Clinical Diabetes Research: Methods and
Techniques”, Ed. Roden M, Wiley’s, London, Great Britain
ISBN 978-0-470-01728-9

Wissenschaftliche Originalarbeiten


+) Glucose uptake saturation explains glucose kinetics profiles measured by different tests. Bizzotto R, Natali A, Gastaldelli A, Muscelli E, Krššák M, Brehm A, Roden M, Ferannini E, Mari A. Am J Physiol Endocrinol Metab. 2016 May 31


+) Modeling glucose and free fatty acid kinetics during insulin-modified intravenous glucose tolerance test in healthy humans: role of counterregulatory response.

Thomaseth K, Brehm A, Pavan A, Pacini G, Roden M.

Am J Physiol Regul Integr Comp Physiol. 2014 Aug 1;307(3):R321-31. doi: 10.1152/ajpregu.00314.2013. Epub 2014 May 21.


+) Lower fasting muscle mitochondrial activity relates to hepatic steatosis in humans. Szendroedi J, Kaul K, Kloock L, Straßburger K, Schmid AI, Chmelik M, Kacerovsky M, Kacerovsky-Bielesz G, Prikoszovich T, Brehm A, Krssák M, Gruber S, Krebs M, Kautzky-Willer A, Moser E, Pacini G, Roden M.

Diabetes Care. 2014 Feb;37(2):468-74. doi: 10.2337/dc13-1359. Epub 2013 Sep 11.

+) Effects of pioglitazone versus glimepiride exposure on hepatocellular fat content in type 2 diabetes. Phielix E, Brehm A, Bernroider E, Krssak M, Anderwald CH, Krebs M, Schmid AI, Nowotny P, Roden M. Diabetes Obes Metab. 2013 Apr 9.


+) Impaired insulin stimulaion of muscular ATP production in patients with typ 1 diabetes. Kacerovsky M, Brehm A, Chmelik M, Schmid AI, Szendroedi J, Kacerovsky-Bielesz G, Nowotny P, Lettner A, Wolzt M, Jones JG, Roden M.

J Intern Med. 2011 Feb;269(2):189-99.

+) Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle. Brehm A, Krssák M, Schmid AI, Nowotny P, Waldhäusl W, Roden M. Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E33-8. Epub 2010 May 4.

+) Abnormal hepatic energy homeostasis in type 2 diabetes. Szendroedi J, Chmelik M, Schmid AI, Nowotny P, Brehm A, Krssak M, Moser E, Roden M. Hepatology. 2009 Oct;50(4):1079-86.

+) Non-invasive assessment of hepatic fat accumulation in chronic hepatitis C by 1H magnetic resonance spectroscopy. Krssák M, Hofer H, Wrba F, Meyerspeer M, Brehm A, Lohninger A, Steindl-Munda P, Moser E, Ferenci P, Roden M. Eur J Radiol. 2010 Jun;74(3):e60-6. Epub 2009 Apr 29.

+) Effects of high-dose simvastatin therapy on glucose metabolism and ectopic lipid deposition in nonobese type 2 diabetic patients. Szendroedi J, Anderwald C, Krssak M, Bayerle-Eder M, Esterbauer H, Pfeiler G, Brehm A, Nowotny P, Hofer A, Waldhäusl W, Roden M. Diabetes Care. 2009 Feb;32(2):209-14. Epub 2008 Oct 28

+) Quantitative ATP synthesis in human liver measured by localized 31P spectroscopy using the magnetization transfer experiment. Schmid AI, Chmelík M, Szendroedi J, Krssák M, Brehm A, Moser E, Roden M. NMR Biomed. 2008 Jun;21(5):437-43.

+) Characterization of hepatic and brain metabolism in young adults with glycogen storage disease type 1: a magnetic resonance spectroscopy study. Weghuber D, Mandl M, Krssák M, Roden M, Nowotny P, Brehm A, Krebs M, Widhalm K, Bischof MG. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1378-84. Epub 2007 Sep 4

+) A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. Weickert MO, Loeffelholz CV, Roden M, Chandramouli V, Brehm A, Nowotny P, Osterhoff MA, Isken F, Spranger J, Landau BR, Pfeiffer AF, Möhlig M. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E1078-84. Epub 2007 Aug 14.

+) Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes. Szendroedi J, Schmid AI, Chmelik M, Toth C, Brehm A, Krssak M, Nowotny P, Wolzt M, Waldhausl W, Roden M. PLoS Med. 2007 May;4(5):e154.

+) The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Krebs M, Brunmair B, Brehm A, Artwohl M, Szendroedi J, Nowotny P, Roth E, Fürnsinn C, Promintzer M, Anderwald C, Bischof M, Roden M. Diabetes. 2007 Jun;56(6):1600-7. Epub 2007 Feb 28.

+) The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests. Brehm A, Thomaseth K, Bernroider E, Nowotny P, Waldhäusl W, Pacini G, Roden M. J Clin Endocrinol Metab. 2006 Jun;91(6):2272-8. Epub 2006 Apr 4.

+) Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans. Bischof MG, Brehm A, Bernroider E, Krssák M, Mlynárik V, Krebs M, Roden M. Eur J Clin Invest. 2006 Mar;36(3):164-9.

+) Changes in hepatic glycogen cycling during a glucose load in healthy humans. Stingl H, Chandramouli V, Schumann WC, Brehm A, Nowotny P, Waldhäusl W, Landau BR, Roden M. Diabetologia. 2006 Feb;49(2):360-8. Epub 2005 Dec 28.

+) Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Brehm A, Krssak M, Schmid AI, Nowotny P, Waldhäusl W, Roden M. Diabetes. 2006 Jan;55(1):136-40.

+) Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, Nowotny P, Waldhäusl W, Marette A, Roden M. Diabetes. 2005 Sep;54(9):2674-84.

+) The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes. Bernroider E, Brehm A, Krssak M, Anderwald C, Trajanoski Z, Cline G, Shulman GI, Roden M. J Clin Endocrinol Metab. 2005 Oct;90(10):5559-65. Epub 2005 Jul 5.

+) Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Krssak M, Brehm A, Bernroider E, Anderwald C, Nowotny P, Dalla Man C, Cobelli C, Cline GW, Shulman GI, Waldhäusl W, Roden M. Diabetes. 2004 Dec;53(12):3048-56.

+) Relationship between serum lipoprotein ratios and insulin resistance in obesity. Brehm A, Pfeiler G, Pacini G, Vierhapper H, Roden M. Clin Chem. 2004 Dec;50(12):2316-22. Epub 2004 Sep 30.

+) Brain energy metabolism during hypoglycaemia in healthy and type 1 diabetic subjects. Bischof MG, Mlynarik V, Brehm A, Bernroider E, Krssak M, Bauer E, Madl C, Bayerle-Eder M, Waldhäusl W, Roden M. Diabetologia. 2004 Apr;47(4):648-51.

+) Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients. Anderwald C, Brabant G, Bernroider E, Horn R, Brehm A, Waldhäusl W, Roden M. Diabetes. 2003 Jul;52(7):1792-8.

+) Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Krebs M, Brehm A, Krssak M, Anderwald C, Bernroider E, Nowotny P, Roth E, Chandramouli V, Landau BR, Waldhäusl W, Roden M. Diabetologia. 2003 Jul;46(7):917-25. Epub 2003 Jun 18.

+)  Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscle. Anderwald C, Bernroider E, Krssak M, Stingl H, Brehm A, Bischof MG, Nowotny P, Roden M, Waldhäusl W. Diabetes. 2002 Oct;51(10):3025-32.

+) Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Krebs M, Krssak M, Bernroider E, Anderwald C, Brehm A, Meyerspeer M, Nowotny P, Roth E, Waldhäusl W, Roden M. Diabetes. 2002 Mar;51(3):599-605.